Urticaria from allergy to a purified human anti-Rh antibody preparation
1995; Wiley; Volume: 50; Issue: 12 Linguagem: Inglês
10.1111/j.1398-9995.1995.tb02511.x
ISSN1398-9995
AutoresIrakly Sulakvelidze, Susan Evans, Iain Switzer, Brian J. Underdown, Joseph Greenbaum, Jerry Dolovich,
Tópico(s)Drug-Induced Adverse Reactions
ResumoThis case presentation describes a young woman who developed generalized urticaria after receiving the human anti-RhD(D) preparation, WinRho, intravenously. Allergy skin tests and the radioallergosorbent test (RAST) for IgE antibodies to the human anti-D immunoglobulin preparation were positive. Further studies using high-pressure liquid chromatography and protein A column chromatography implicated a nonimmunoglobulin low-molecular-weight contaminant. This case report illustrates an allergic reaction to a highly purified human immunoglobulin preparation, and demonstrates approaches to assessment of such a reaction.
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