Portal de Periódicos da CAPES

Evidence for the Involvement of Macrophage-Derived Nitric Oxide in the Immunomodulatory Effect of Morphine and Aversive Pavlovian Conditioning

1995; Springer Nature; Linguagem: Inglês

10.1007/978-1-4615-1951-5_19

2214-8019

Donald T. Lysle, Karamarie Fecho, Kimberly A. Maslonek, Linda Dykstra,

Pain Mechanisms and Treatments

It is well established that in vivo administration of morphine to rats produces alterations in several in vitro measures of immune status. For example, our work has shown that the administration of morphine to Lewis rats induces a dose-dependent reduction in the proliferative response of splenic and blood lymphocytes, a reduction in the production of interleukin-2 and γ-interferon, and a reduction in the cytotoxic response of natural killer cells. Furthermore, we have shown that administration of the opioid antagonist, naltrexone, dose-dependently antagonizes the immunomodulatory effects of morphine, indicating that the immunomodulatory effects of morphine are mediated by activity at opioid receptors1.