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High-resolution antibody dynamics of vaccine-induced immune responses

2014; National Academy of Sciences; Volume: 111; Issue: 13 Linguagem: Inglês

10.1073/pnas.1323862111

1091-6490

Uri Laserson, François Vigneault, Daniel Gadala-Maria, Gur Yaari, Mohamed Uduman, Jason A. Vander Heiden, William Kelton, Sang Taek Jung, Yi Liu, Jonathan Laserson, Raj Chari, Je-Hyuk Lee, Ido Bachelet, Brendan Hickey, Erez Lieberman-Aiden, Bozena Hanczaruk, Birgitte B. Simen, Michael D. Miller, Daphne Koller, George Georgiou, Steven H. Kleinstein, George M. Church,

vaccines and immunoinformatics approaches

Significance The immune system must constantly adapt to combat infections and other challenges. This is accomplished by continuously evolving the antibody repertoire, and by maintaining memory of prior challenges. By using next-generation DNA sequencing technology, we have examined the shear amount of antibody made by individuals during a flu vaccination trial. We demonstrate one of the first characterizations of the fast antibody dynamics through time in multiple individuals responding to an immune challenge.