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Cell-Permeable Near-Infrared Fluorogenic Substrates for Imaging β-Lactamase Activity

2005; American Chemical Society; Volume: 127; Issue: 12 Linguagem: Inglês

10.1021/ja042829+

1943-2984

Bengang Xing, Ashot Khanamiryan, Jianghong Rao,

Photodynamic Therapy Research Studies

This communication describes a design of cell-permeable near-infrared fluorogenic substrates for imaging beta-lactamase expression in living mammalian cells. This design is based on fluorescence energy transfer resonance and utilizes a peracetylated d-glucosamine to facilitate the transport of the near-infrared probe across cell membranes. This new type of fluorogenic probe may also be applied to image gene expression in living animals.