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Role of PML in Cell Growth and the Retinoic Acid Pathway

1998; American Association for the Advancement of Science; Volume: 279; Issue: 5356 Linguagem: Inglês

10.1126/science.279.5356.1547

1095-9203

Zhu Gang Wang, Laurent Delva, Mirella Gáboli, Roberta Rivi, Marco Giorgio, Carlos Cordon‐Cardo, Frank Grosveld, Pier Paolo Pandolfi,

Acute Myeloid Leukemia Research

The PML gene is fused to the retinoic acid receptor alpha (RARalpha) gene in chromosomal translocations associated with acute promyelocytic leukemia (APL). Ablation of murine PML protein by homologous recombination revealed that PML regulates hemopoietic differentiation and controls cell growth and tumorigenesis. PML function was essential for the tumor-growth-suppressive activity of retinoic acid (RA) and for its ability to induce terminal myeloid differentiation of precursor cells. PML was needed for the RA-dependent transactivation of the p21WAF1/CIP1 gene, which regulates cell cycle progression and cellular differentiation. These results indicate that PML is a critical component of the RA pathway and that disruption of its activity by the PML-RARalpha fusion protein may be important in APL pathogenesis.