Isolation by HPLC and characterisation of the bioactive fraction of New Zealand manuka (Leptospermum scoparium) honey
2008; Elsevier BV; Volume: 343; Issue: 4 Linguagem: Inglês
10.1016/j.carres.2007.12.011
ISSN1873-426X
AutoresDavid R. Adams, Cherie H. Boult, Benjamin J. Deadman, Judie M. Farr, Megan N.C. Grainger, Merilyn Manley‐Harris, Melanie J. Snow,
Tópico(s)Essential Oils and Antimicrobial Activity
ResumoUsing HPLC a fraction of New Zealand manuka honey has been isolated, which gives rise to the non-peroxide antibacterial activity. This fraction proved to be methylglyoxal, a highly reactive precursor in the formation of advanced glycation endproducts (AGEs). Methylglyoxal concentrations in 49 manuka and 34 non-manuka honey samples were determined using a direct detection method and compared with values obtained using standard o-phenylenediamine derivatisation. Concentrations obtained using both the methods were similar and varied from 38 to 828 mg/kg.
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