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Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis

2004; American Association for the Advancement of Science; Volume: 306; Issue: 5705 Linguagem: Inglês

10.1126/science.1104935

1095-9203

Paul A. Gray, Hui Fu, Ping Luo, Qing Zhao, Jing Yu, Annette Ferrari, Toyoaki Tenzen, Dongin Yuk, Eric F. Tsung, Zhaohui Cai, John A. Alberta, Leping Cheng, Yang Liu, Jan M. Stenman, M. Todd Valerius, Nathan Billings, Haesun A. Kim, Michael E. Greenberg, Andrew P. McMahon, David H. Rowitch, Charles D. Stiles, Qiufu Ma,

Machine Learning in Bioinformatics

In the developing brain, transcription factors (TFs) direct the formation of a diverse array of neurons and glia. We identifed 1445 putative TFs in the mouse genome. We used in situ hybridization to map the expression of over 1000 of these TFs and TF-coregulator genes in the brains of developing mice. We found that 349 of these genes showed restricted expression patterns that were adequate to describe the anatomical organization of the brain. We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database.