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Propylthiouracil-Induced Cholestatic Jaundice

1986; Marcel Dekker; Volume: 24; Issue: 4 Linguagem: Inglês

10.3109/15563658608992599

1097-9875

Daniel S. Seidman, E Livni, Bianca Ilie, Ilana Blum,

Drug-Induced Hepatotoxicity and Protection

The typical propylthiouracil (PTU)-linked hepatotoxicity, is known to manifest itself by hepatocellular injury with greatly increased serum transaminase values and evidence of hepatic necrosis on liver biopsy. Herewith presented is a 33-year old, thyrotoxic woman who developed cholestatic jaundice two weeks after initiation of PTU therapy. The diagnosis was confirmed by liver biopsy. A causal link between PTU treatment and the cholestatic jaundice was suggested by: the time of onset, typical skin rash and a positive migration inhibition factor (MIF) test to PTU.Awareness of this rare complication of PTU treatment may prevent the performance of unnecessary, expensive and possibly harmful diagnostic procedures.