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Erbium:YAG Laser and Cultured Epidermis in the Surgical Therapy of Stable Vitiligo

2003; American Medical Association; Volume: 139; Issue: 10 Linguagem: Inglês

10.1001/archderm.139.10.1303

1538-3652

Liliana Guerra, Grazia Primavera, Desanka Raskovic, Graziella Pellegrini, Osvaldo Golisano, Sergio Bondanza, Patrizia Paterna, Giulio Sonego, Tommaso Gobello, Francesco Atzori, Paolo Piazza, A. Luci, Michele De Luca,

Corneal Surgery and Treatments

Objective: To induce complete and reproducible repigmentation of large "stable" vitiligo lesions by means of autologous cultured epidermal grafts using a rapid, simple, and minimally invasive surgical procedure.Design: Achromic epidermis was removed by means of appropriately settled erbium:YAG laser, and autologous epidermal grafts were applied onto the recipient bed.Melanocyte content was evaluated by dopa reaction.The percentage of repigmentation was calculated using a semiautomatic image analysis system.Setting: A biosafety level 3-type cell culture facility, a surgical ambulatory department, and a dermatological department in a hospital.Patients: Twenty-one patients with different types of vitiligo were admitted to the study and treated with autologous cultured epidermal grafts.Inclusion criteria were failure of at least 2 standard medical approaches; no therapy