Correlation between plasma levels of prolactin and chlorpromazine in psychiatric patients
1975; Cambridge University Press; Volume: 5; Issue: 2 Linguagem: Inglês
10.1017/s0033291700056488
ISSN1469-8978
AutoresT. Kolakowska, D. H. Wiles, A. S. McNeilly, Michael Gelder,
Tópico(s)Bipolar Disorder and Treatment
ResumoPlasma levels of chlorpromazine (CPZ) and prolactin were measured repeatedly in 14 psychiatric patients throughout CPZ treatment. Mean prolactin level was elevated in 11 subjects (all six women and five of eight men). Mean plasma prolactin correlated significantly with mean plasma CPZ but not with the dose of the drug. Only patients with mean plasma prolactin above 35 ng/ml developed Parkinsonian side-effects.
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