Development of the biocatalytic resolution of 2-azabicyclo[2.2.1]hept-5-en-3-one as an entry to single-enantiomer carbocyclic nucleosides
1993; Elsevier BV; Volume: 4; Issue: 6 Linguagem: Inglês
10.1016/s0957-4166(00)80218-9
ISSN1362-511X
AutoresStephen J. Taylor, Raymond McCague, Richard Wisdom, Carol Lee, Karen Dickson, Graham Ruecroft, Fergal O'Brien, Jennifer A. Littlechild, Jennifer Bevan, Stanley M. Roberts, Christopher Thomas Evans,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoFor the resolution of the bicyclic lactam 2-azabicyclo[2.2.1]hept-5-en-3-one, efficient whole cell biocatalysts have been identified and from these, enzymes (lactamases) have been isolated. While the two enzymes obtained act on different enantiomers of the lactam, either can be used in scaleable processes to obtain synthons for carbocyclic nucleosides having the natural configuration.
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