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BIBTEX RIS

Transition from interleukin 1 beta (IL-1 beta) to IL-1 alpha production during maturation of inflammatory macrophages in vivo.

1992; Rockefeller University Press; Volume: 175; Issue: 6 Linguagem: Inglês

10.1084/jem.175.6.1793

ISSN

1540-9538

Autores

H U Beuscher, U P Rausch, Ivan G. Otterness, Martin Röllinghoff,

Tópico(s)

Immune Response and Inflammation

Resumo

In situ production of interleukin 1 alpha (IL-1 alpha) and IL-1 beta was investigated in Peyer's patches (PP) of mice undergoing an acute bacterial infection with Yersinia enterocolitica O8. Synthesis of IL-1 beta, as determined by immunohistochemistry, was found primarily in monocytes migrating into the inflamed PP. In comparison, synthesis of IL-1 alpha was temporarily delayed by at least 24 h and was only found in mature macrophages, which did not produce detectable levels of IL-1 beta. This indicates a transition from IL-1 beta to IL-1 alpha production during maturation of monocytes into inflammatory macrophages, and further emphasizes a dichotomy between IL-1 alpha and IL-1 beta.

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