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DNA/ANTI‐DNA complexes

1981; Wiley; Volume: 24; Issue: 5 Linguagem: Inglês

10.1002/art.1780240504

1529-0131

Steven J. Waller, Ronald P. Taylor, E L Wright, Kathi W. Morley, Mark D. Johns,

Systemic Lupus Erythematosus Research

Abstract The hydrodynamic sizes of antibody/ 3 H‐dsDNA immune complexes are correlated with their ability to fix complement in a red blood cell‐complement linked binding assay. The results with PM2 dsDNA and a sonicated preparation (with a molecular weight of approximately 5 . 10 5 ) suggest that packing considerations are also important in the complement binding reaction. The relevance of these findings with respect to the role of antibody/dsDNA immune complexes in the pathogenesis of glomerulonephritis in systemic lupus erythematosus is discussed.