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Effects of the Opiate Antagonist Naloxone and the Enkephalin Analog DAMME on the Vasopressin Response to a Hypertonic Stimulus in Man

1980; Oxford University Press; Volume: 51; Issue: 6 Linguagem: Inglês

10.1210/jcem-51-6-1447

1945-7197

Stafford L. Lightman, Nicola Langdon, Mary L. Forsling,

Neuropeptides and Animal Physiology

Experiments were performed to study the effects of opioids on both the plasma arginine vasopressin and renal responses to hypertonic saline. Neither the opiate antagonist naloxone nor the enkephalin agonist DAMME [D-Ala2, MePhe4, Met (0)-ol)enkephalin] altered the vasopressin response to the same hypertonic stimulus, although DAMME increased free water clearance. In man, opioids do not seem to be important mediators of the vasopressin response to osmolar change.