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The Presence of Anti‐Tat Antibodies Is Predictive of Long‐Term Nonprogression to AIDS or Severe Immunodeficiency: Findings in a Cohort of HIV‐1 Seroconverters

2005; Oxford University Press; Volume: 191; Issue: 8 Linguagem: Inglês

10.1086/428909

1537-6613

Giovanni Rezza, Valeria Fiorelli, Maria Dorrucci, Massimo Ciccozzi, Antonella Tripiciano, Arianna Scoglio, Barbara Collacchi, Maria Josefina Ruiz Alvarez, Concettina Giannetto, Antonella Caputo, Lina Rachele Tomasoni, Francesco Castelli, Mauro Sciandra, Alessandro Sinicco, Fabrizio Ensoli, Stefano Buttò, Barbara Ensoli,

Immune Cell Function and Interaction

The human immunodeficiency virus (HIV) type 1 Tat protein plays a key role in the life cycle of the virus and in pathogenesis and is highly conserved among HIV subtypes. On the basis of this and of safety, immunogenicity, and efficacy findings in monkeys, Tat is being tested as a vaccine in phase 1 trials. Here, we evaluated the incidence and risk of progression to advanced HIV disease by anti-Tat serostatus in a cohort of 252 HIV-1 seroconverters. The risk of progression was lower in the anti-Tat-positive subjects than in the anti-Tat-negative subjects. Progression was faster in the persistently anti-Tat-negative subjects than in the transiently anti-Tat-positive subjects, and no progression was observed in the persistently anti-Tat-positive subjects.