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Recent Advances in the Development of HIV-1 Vaccines Using Replication-Incompetent Adenovirus Vectors

2004; Annual Reviews; Volume: 55; Issue: 1 Linguagem: Inglês

10.1146/annurev.med.55.091902.104344

1545-326X

John W. Shiver, Emilio A. Emini,

Virus-based gene therapy research

An increasing body of evidence suggests that a vaccine that elicits anti-HIV-1 cellular immunity could provide the basis for an effective AIDS vaccine. Comparative immunization experiments testing a variety of vaccine approaches have demonstrated that replication-incompetent adenovirus vectors are an effective means for eliciting cytotoxic T-lymphocyte (CTL) immune responses against HIV-1 antigens. These immune responses effectively control viremia in nonhuman primates following challenge with simian AIDS viruses. Such data, coupled with epidemiology studies that identify HIV-1 gag, pol, and nef as the best antigens for broadly directed cellular immune responses, provide guidance for the development of a potential AIDS vaccine.