Mechanisms of Cisplatin Ototoxicity and Routes for Intervention
2011; American Speech–Language–Hearing Association; Volume: 15; Issue: 1 Linguagem: Inglês
10.1044/hhd15.1.3
ISSN1940-7661
AutoresEric C. Bielefeld, Donald Henderson,
Tópico(s)Molecular Sensors and Ion Detection
ResumoNo AccessPerspectives on Hearing and Hearing Disorders: Research and DiagnosticsArticle1 Apr 2011Mechanisms of Cisplatin Ototoxicity and Routes for Intervention Eric C. Bielefeld, and Donald Henderson Eric C. Bielefeld Department of Speech and Hearing Science, The Ohio State UniversityColumbus, OH Google Scholar and Donald Henderson Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at BuffaloBuffalo, NY Google Scholar https://doi.org/10.1044/hhd15.1.3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In Abstract Cisplatin is a potent chemotherapy drug that is still used frequently in spite of its many toxic side effects, of which ototoxicity is among the most severe. Modern research has provided new insights into the biological mechanisms of cisplatin-induced cochlear damage and has opened new avenues for co-treatments to potentially reduce or eliminate the ototoxicity. As has proven to be the case with noise-induced hearing loss and age-related hearing loss, oxidative stress has a key role in cisplatin ototoxicity. Additionally, like with noise and aging, apoptotic cell death has been identified as the primary mode of cell death in cochleae exposed to cisplatin. The current review begins with a description of cisplatin ototoxicity and its mechanisms. Interventions that target a reduction of oxidative stress or intercession in the apoptotic cell death pathway as a means of limiting cisplatin-induced hearing loss are then discussed in the second half of the review. References Alam, S. A., Ikeda, K., Oshima, T., Suzuki, M., Kawase, T., Kikuchi, T., … et al.. (2000). 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Google Scholar Additional Resources FiguresReferencesRelatedDetailsCited byPerspectives of the ASHA Special Interest Groups (1-10)A Tale of Two Susceptibilities: Cisplatin Ototoxicity Variability in Similar PatientsAmy Custer Volume 15Issue 1April 2011Pages: 3-14 Get Permissions Add to your Mendeley library History Published in issue: Apr 1, 2011 Metrics Topicsasha-topicsasha-sigsasha-article-typesleader-topicsCopyright & Permissions© 2011 American Speech-Language-Hearing AssociationPDF downloadLoading ...
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