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Laser Fluence for Permanent Damage of Cutaneous Blood Vessels

1999; Wiley; Volume: 70; Issue: 6 Linguagem: Inglês

10.1111/j.1751-1097.1999.tb08302.x

1751-1097

Jennifer K. Barton, Gracie Vargas, T. Joshua Pfefer, Ashley J. Welch,

Laser Material Processing Techniques

Abstract Treatment of vascular disorders may be improved by a more thorough understanding of laser‐blood vessel interaction. In this study, the probability of permanent damage to a given type and size of blood vessel was determined as a function of fluence at the top (superficial edge) of the vessel lumen. A 532 nm wavelength, 10 ms pulse duration, 3 mm spot size laser was used to perform approximately 250 irradiations of subdermal blood vessels in the hamster dorsal skin flap preparation. The radiant exposure required for a 50% probability of permanent damage was calculated using a probit analysis of experimental results. Threshold radiant exposure increased with larger blood vessel diameters and was greater for arterioles than venules. Monte Carlo modeling of a typical blood vessel geometry revealed that fluence at the top of the blood vessel lumen was amplified by a factor of approximately 2.4 over tissue surface radiant exposure, due to light scattering in the tissue and internal reflection at the skin‐air interfaces.