Portal de Periódicos da CAPES

Fatal Overdosage with Nefopam (Acupan®)

2002; Oxford University Press; Volume: 26; Issue: 4 Linguagem: Inglês

10.1093/jat/26.4.239

1945-2403

A. Tracqui, L. Berthelon, Bertrand Ludes,

Ion channel regulation and function

This paper presents a fatality due to massive, intravenous self-administration of nefopam (Acupan), a non-opiate central analgesic, in a 37-year-old female. Nefopam was measured in various postmortem samples by means of high-pressure liquid chromatography coupled to mass spectrometry via an ionspray interface. Heart blood concentration was 4.38 µg/mL and exceeded by approximately 30 times the highest therapeutic levels with the usual reservations concerning possible postmortem redistribution. This is only the third case of death following nefopam overdose reported in the literature.