Portal de Periódicos da CAPES

Rutin potentiates insulin receptor kinase to enhance insulin-dependent glucose transporter 4 translocation

2014; Wiley; Volume: 58; Issue: 6 Linguagem: Inglês

10.1002/mnfr.201300691

1613-4133

Chia‐Yu Hsu, Hung-Yuan Shih, Yi‐Chen Chia, Chia‐Hung Lee, Hitoshi Ashida, Yiu‐Kay Lai, Ching‐Feng Weng,

Pancreatic function and diabetes

Scope We investigated whether rutin, a flavonoid isolated from Toona sinensis Roem, has the ability to enhance insulin-dependent receptor kinase (IRK) activity and glucose transporter 4 (GLUT4) translocation in differentiated myotubes. We also tested the effects of rutin treatment in insulin-resistant mice using an oral glucose tolerance test (OGTT). Methods and results Rutin potentiated insulin receptor kinase (IRK) phosphorylation when IRK autophosphorylation was triggered by insulin in differentiated myotubes. Co-treatment of cells with rutin and insulin attenuated S961-mediated inhibition of insulin-dependent GLUT4 translocation. In S961-treated C57BL/6 mice, an in vivo model of insulin resistance and type 2 diabetes, rutin treatment showed a normoglycemic effect in the OGTT. Conclusion This study shows evidence that rutin may serve as a potential agent for glycemic control through enhancement of IRK activity, thereby inducing the insulin signaling pathway causing increased GLUT4 translocation and increased glucose uptake.