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BIBTEX RIS

SMART: a web-based tool for the study of genetically mobile domains

2000; Oxford University Press; Volume: 28; Issue: 1 Linguagem: Inglês

10.1093/nar/28.1.231

ISSN

1362-4962

Autores

J. Schultz,

Tópico(s)

Genomics and Phylogenetic Studies

Resumo

SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures (http://SMART.embl-heidelberg.de ). More than 400 domain families found in signalling, extra­cellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system. User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa.

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