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Antimicrobial susceptibility pattern and ESBL prevalence in Klebsiella pneumoniae from urinary tract infections in the North-West of Pakistan

2009; Academic Journals; Volume: 3; Issue: 11 Linguagem: Inglês

10.5897/ajmr.9000090

1996-0808

Farhat Ullah, Salman Akbar Malik, Jawad Ahmed,

Nephrotoxicity and Medicinal Plants

Urinary Tract Infections (UTIs) are the most prevalent infections worldwide both in males and females. Klebsiella is one of the major pathogens causing UTIs. These bacteria also produce enzymes called Extended Spectrum Beta-Lactamases (ESBL) which render penicillins and cephalosporins inactive. The present study included 92 Klebsiella pneumoniae, isolated from urine of patients suffering from UTIs. Antibiotic susceptibility testing and ESBL detection were carried out according to Clinical and Laboratory Standards Institute (CLSI) criteria. Eighteen antibiotics were tested in this study. A total of 54 (58.7%) isolates were found to be ESBL producers. Seventy one percent isolates were resistant to 3 or more antibiotics (Multidrug resistant). Imipenem and meropenem showed high potency with 93.48 and 86.96% isolates being susceptible respectively. Susceptibility to gentamicin was 17.39%; kanamycin 63.04%; gatifloxacin 45.65; ciprofloxacin 41.3%; enoxacin 43.48%; doxycycline 15.22% and to co-trimoxazole only 6.52%. This study reveals that Klebsiella isolated from UTI in this region are multi-drug resistant and produce ESBL in large proportions. Key words: Antibiotic resistance, Klebsiella pneumoniae, urinary tract infections, extended spectrum beta lactamase.