Microchip Technology for Automated and Parallel Patch‐Clamp Recording
2006; Wiley; Volume: 2; Issue: 7 Linguagem: Inglês
10.1002/smll.200600083
ISSN1613-6829
AutoresAndrea Brüggemann, Sonja Stoelzle, Michael George, Jan C. Behrends, Niels Fertig,
Tópico(s)Microfluidic and Capillary Electrophoresis Applications
ResumoAbstract The patch‐clamp technique is the state‐of‐the‐art technology for the study of a large class of membrane proteins called ion channels. Ion channels mediate electrical current flow, have crucial roles in cellular physiology, and are important drug targets. However, patch clamping is a laborious process requiring a skilled experimenter and is, therefore, not compatible with the high throughput needed in drug development. The solution for automated and parallel patch‐clamp measurements that is provided by microchip technology is presented here.
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