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Ceftazidime-Related Nonconvulsive Status Epilepticus

1994; American Medical Association; Volume: 154; Issue: 5 Linguagem: Inglês

10.1001/archinte.1994.00420050158014

1538-3679

Amy D. Klion, Jeffrey Kallsen, Clayton T. Cowl, William M. Nauseef,

Leprosy Research and Treatment

The third-generation cephalosporin, ceftazidime, is widely used for the treatment of serious gram-negative infections. As is true of cephalosporins in general, reported adverse effects have been few. We report a case of ceftazidime-induced status epilepticus in a patient with Pseudomonas aeruginosa meningitis and compare the clinical manifestations of this case with those of two previously described cases of ceftazidime-related encephalopathy. This diagnosis should be entertained and an electroencephalogram should be obtained in all patients with myoclonus and/or altered mental status while they are receiving ceftazidime therapy.