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Cell-mediated immunity to Chlamydia pneumoniae measured as lymphocyte blast transformation in vitro

1993; American Society for Microbiology; Volume: 61; Issue: 5 Linguagem: Inglês

10.1128/iai.61.5.2196-2199.1993

1098-5522

Heljä‐Marja Surcel, Hannu Syrjälä, M. Leinonen, Pekka Saikku, Elja Herva,

Cervical Cancer and HPV Research

The purpose of the present study was to analyze Chlamydia pneumoniae-induced, antigen-specific, cell-mediated immunity. Peripheral blood mononuclear cells of four persons infected with C. pneumoniae Kajaani 6 and 17 healthy volunteers were stimulated with antigen composed of whole elementary bodies of C. pneumoniae Kajaani 6 (CP-Ag). Definitive antigen-specific lymphoproliferation (LP) responses were developed after recent infection. The LP responses of healthy people to CP-Ag varied considerably. There was no clear correlation between LP responses to CP-Ag and those to an antigen prepared from Chlamydia trachomatis serotype L2 (r > or = 0.50, P < 0.1). A larger study is required to demonstrate whether the LP responses to CP-Ag can be used for the diagnosis of C. pneumoniae infection.