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SPINAL CORD TRANSECTION IN RATS: THE THERAPEUTIC EFFECTS OF DIMETHYL SULFOXIDE AND HYPERBARIC OXYGEN*

1983; Wiley; Volume: 411; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1983.tb47303.x

1749-6632

John B. Gelderd, W. P. Fife, Daniel E. Bowers, S. H. Deschner, D W Welch,

Nitric Oxide and Endothelin Effects

Annals of the New York Academy of SciencesVolume 411, Issue 1 p. 218-233 SPINAL CORD TRANSECTION IN RATS: THE THERAPEUTIC EFFECTS OF DIMETHYL SULFOXIDE AND HYPERBARIC OXYGEN* John B. Gelderd, John B. Gelderd Department of Anatomy College of MedicineSearch for more papers by this authorW. P. Fife, W. P. Fife Department of Biology College of Science Texas A&M University College Station, Texas 77843Search for more papers by this authorD. E. Bowers, D. E. Bowers Section of Anatomy School of Dental Medicine Southern Illinois University Alton, Illinois 62014Search for more papers by this authorS. H. Deschner, S. H. Deschner Department of Anatomy College of MedicineSearch for more papers by this authorD. W. Welch, D. W. Welch Department of Biology College of Science Texas A&M University College Station, Texas 77843Search for more papers by this author John B. Gelderd, John B. Gelderd Department of Anatomy College of MedicineSearch for more papers by this authorW. P. Fife, W. P. Fife Department of Biology College of Science Texas A&M University College Station, Texas 77843Search for more papers by this authorD. E. Bowers, D. E. Bowers Section of Anatomy School of Dental Medicine Southern Illinois University Alton, Illinois 62014Search for more papers by this authorS. H. Deschner, S. H. Deschner Department of Anatomy College of MedicineSearch for more papers by this authorD. W. Welch, D. W. Welch Department of Biology College of Science Texas A&M University College Station, Texas 77843Search for more papers by this author First published: June 1983 https://doi.org/10.1111/j.1749-6632.1983.tb47303.xCitations: 12 * Supported by a grant from Paralysis Cure Research Foundation. 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The Spinal Cord and Its Reaction to Traumatic Injury. Marcel Dekker. New York . 6 C. C. Kao, R. P. Bunge & P. J. Reier, Eds. 1983. Spinal Cord Reconstruction. Raven Press. New York . 7 Gelderd, J. B., M. A. Matthews, M. F. ST. Onge & C. L. Faciane. 1980. Qualitative and quantitative effects of ACTH, Piromen, Cytoxan and isobutyl-2-cyanoacrilate treatments following spinal cord transection in rats. Acta Neurobiol. Exp. (Warsz.). 40: 489– 500. 8 Osterholm, J. L. 1978. The Pathophysiology of Spinal Cord Trauma. Charles C. Thomas. Springfield , Ill . 9 Goldsmith, H. S., E. Steward, W. F. Chen & S. Duckett. 1983. Application of intact omentum to the normal & traumatized spinal cord. In Spinal Cord Reconstruction. C. C. Kao, R. P. Bunge, & P. J. Reier, Eds.: 235– 244. Raven Press. New York . 10 De la Torre, J. C. 1980. Chemotherapy of spinal cord trauma. In The Spinal Cord and its Reaction to Traumatic Injury. W. Windle, Ed.: 291– 310. Marcel Dekker. New York . 11 De la Torre, J. C. 1981. Spinal cord injury: Review of basic and applied research. Spine 6: 315– 355. 12 Hartzog, J. T., R. G. Fisher & C. Snow. 1969. Spinal cord trauma: Effect of hyperbaric oxygen therapy. Proc. Ann. Clin. Spinal Cord Inj. Cong. 17: 70. 13 Holbach, K. H., H. Wassmann & D. Linke. 1977. The use of hyperbaric oxygenation in the treatment of spinal cord lesions. Exp. Neurol. 16: 213– 221. 14 Jones, R. F., I. P. Unsworth & J. E. Marasszeky. 1978. Hyperbaric oxygen and acute spinal cord injuries in humans. Med. J. Aust. 2: 573– 575. 15 Linke, D., K. H. Holbach, H. Wassmann & K. L. Hoheluchter. 1975. Electromyographic surveillance of hyperbaric oxygenation treatment (HO) of spinal lesions. In Forensic Problems in Neurosurgery. W. Klug, M. Brock, M. Klinger & O. Spoerri, Eds.: 268– 271. Springer-Verlag. New York . 16 Kelly, D. L., Jr., K. R. L. Lassiter, A. Vongswivert & J. M. Smith. 1972. Effects of hyperbaric oxygenation and tissue oxygen studies in experimental paraplegia. J. Neurosurg. 36: 425– 429. 17 Yeo, J. D., B. McKenzie, B. Hardwood & A. Kidman. 1976. Treatment of paraplegic sheep with hyperbaric oxygen. Med. J. Aust. 1: 538– 540. 18 Yeo, J. D., S. Stabback & B. McKenzie. 1977. A study of the effects of hyperbaric oxygen on the experimental spinal cord injury. Med. J. Aust. 2: 145– 147. 19 Brown, F. D., L. M. Johns & S. Mullan. 1980. Dimethyl sulfoxide in experimental brain injury, with comparison to mannitol. J. Neurosurg. 53: 58– 62. 20 De la Torre, J. C., K. Kajihara, D. W. Rowed, J. M. Kawanaga & J. F. Mullan. 1972. Modification of experimental head and spinal cord injuries using dimethyl sulfoxide. Trans. Amer. Neurol. Assoc. 97: 203– 233. 21 De la Torre, J. D., C. M. Johnson, L. H. Harris, K. Kajihara & S. Mullan. 1974. Monoamine changes in experimental head and spinal cord trauma: Failure to confirm previous observations. Surg. Neurol. 2: 5. 22 De la Torre, J. D., C. M. Johnson, D. J. Goode & S. Mullan. 1975. Pharmacologic treatment and evaluation of permanent experimental spinal cord trauma. Neurology 25: 508– 514. 23 De la Torre, J. C., H. M. Kawanaga, D. W. Rowed, C. M. Johnson, D. L. Goode, K. Kajihara & S. Mullan. 1975. Dimethyl sulfoxide in central nervous system trauma. Ann. N.Y. Acad. Sci. 243: 362– 389. 24 De la Torre, J. C. & J. W. Surgeon. 1976. Dexamethasone and DMSO in experimental transorbital infarction. Stroke 7(6): 577– 583. 25 De la Torre, J. C., J. W. Surgeon, P. K. Hill & T. Khan. 1977. DMSO in the treatment of brain infarction: Basic considerations. In Arterial Air Embolism and Acute Stroke. J. M. Hallenbeck & L. Greenbaum, Eds.: 138. Undersea Med. Soc. Bethesda , Md . 26 Kajihara, K., H. Kawanaga, J. C. de la Torre & S. Mullan. 1973. Dimethyl sulfoxide in the treatment of experimental acute spinal cord injury. Surg. Neurol. 1: 16– 22. 27 McCallum, J. E. & M. H. Bennett. 1976. DMSO as a therapeutic agent in chronic spinal cord compression. Program. Abstr. 26th Ann. Mtg. Cong, of Neurol. Surg. p. 166. New Orleans . 28 Lim, R. & S. Mullan. 1975. Protective effect of dimethyl sulfoxide on brain cells against sonic stress. Ann. N.Y. Acad. Sc. 243: 358– 361. 29 Mead, C. O., R. A. Moody, S. Ruamsuki & S. Mullan. 1970. Effect of isovalemic hemodilution of cerebral blood flow following experimental head injury. J. Neurosurg. 32: 40– 50. 30 Bodian, D. 1936. A new method for staining nerve fibers and nerve endings in mounted paraffin sections. Anat. Rec. 65: 89– 97. 31 Gomori, G. 1950. A rapid one step trichrome stain. Am. J. Clin. Pathol. 20: 661– 664. 32 Kao, C. C. & L. W. Chang. 1977. The mechanism of spinal cord cavitation following spinal cord transection. I. A correlated histochemical study. J. Neurosurg. 46: 197– 209. 33 Kao, C. C., L. W. Chang & J. M. B. Bloodworth. 1977. The mechanism of spinal cord cavitation following spinal cord transection. II. Electron microscopic observations. J. Neurosurg. 40: 745– 756. 34 Kao, C. C., L. W. Chang & J. M. B. Bloodworth. 1977. The mechanism of spinal cord cavitation following spinal cord transection. III. Delayed grafting with and without spinal cord retransection. J. Neurosurg. 46: 757– 766. 35 Kao, C. C., L. W. Chang & J. M. B. Bloodworth. 1977. Axonal regeneration across transected mammalian spinal cords: An electron microscopic study of delayed microsurgical nerve grafting Exp. Neurol. 54: 591– 615. 36 Kao, C. C. 1980. Spinal cord cavitation after injury. In The Spinal Cord and its Reaction to Traumatic Injury. W. F. Windle, Ed.: 249– 270. Marcel Dekker. New York . 37 Feringa, E. R., J. S. Wendt & R. D. Johnson. 1974. Immunosuppressive treatment to enhance spinal cord regeneration in rats. Neurology (Minneapolis) 24: 287– 293. 38 Feringa, E. R., R. D. Johnson & J. S. Wendt. 1975. Spinal cord regeneration in rats after immunosuppressive treatment. Arch. Neurol. 22: 676– 683. 39 Feringa, E. R., W. K. Kinnin & A. G. Britten. 1976. Recovery in rats after spinal cord injury. Neurology (Minneapolis) 26: 839– 843. 40 A. M. Michelson, J. M. McCord & I. Fridovitch, Eds. 1977. Superoxide and Superoxide Dismutases. Academic Press. New York . 41 Ogilvie, R. W. & J. D. Balentine. 1973. Oxygen tensions in the deep gray matter of rats exposed to hyperbaric oxygen. Adv. Exp. Med. Biol. 37: 299– 304. 42 Ogilvie, R. W. & J. D. Balentine. 1975. Oxygen tension in spinal cord gray matter during exposure to hyperbaric oxygen. J. Neurosurg. 43: 156– 161. 43 Clemente, C. D. 1955. Structural regeneration in the mammalian central nervous system and the role of neuroglia and connective tissue. In Regeneration in the Central Nervous System. W. F. Windle, Ed.: 147– 161. Charles C. Thomas. Springfield , Ill . 44 Hunt, T. K., J. Nunikoski, B. H. Zederfeldt & I. A. Silver. 1977. Oxygen in wound healing enhancement; cellular effects of oxygen. In Hyperbaric Oxygen Therapy. J. C. Davis & T. K. Hunt, Eds. Undersea Med. Soc. Bethesda , Md . 45 Juva, K., D. J. Prockop, G. W. Cooper & J. W. Lash. 1966. Hydroxylation of proline and the intracellular accumulation of a polypeptide precursor of collagen. Science 152: 92. 46 Hart, G. B. 1976. Indications and contraindications for hyperbaric oxygen therapy. J. Am. Med. Assoc. 236: 1892. 47 Gelderd, J. B., D. W. Welch, W. P. Fife & D. E. Bowers, Jr. 1980. Therapeutic effects of hyperbaric oxygen and dimethyl sulfoxide following spinal cord transection in rats. Undersea Biomed. Res. 7: 305– 320. 48 Gelderd, J. 1983. Hyperbaric oxygen and dimethyl sulfoxide therapy following spinal cord injury. In Spinal Cord Reconstruction. C. C. Kao, R. P. Bunge & P. J. Reier, Eds. Raven Press. New York . 49 Weissman, G., G. Sessa & V. Bevans. 1967. Effect of DMSO on the stabilization of lysosomes by cortisone and chloroquine in vitro. Ann. N.Y. Acad. Sci. 141: 326– 332. 50 Ederbaum, A. I., E. Dicker, E. Rubin & G. Cohen. 1977. The effect of dimethyl sulfoxide and other hydroxyl radical scavengers on the oxidation of ethanol by rat liver microscomes. Biochem. Biophys. Res. Commun. 78(4): 1254– 1262. 51 Berliner, D. L. 1967. The influence of dimethyl sulfoxide on fibroblastic proliferation. Ann. N.Y. Acad. Sci. 141: 159– 164. 52 Gries, G. 1971. Some effects of DMSO on connective tissue. In Dimethyl Sulfoxide. S. W. Jacob, E. E. Rosenbaum & D. C. Wood, Eds.: 325– 336. Marcel Dekker. New York . 53 Matinian, L. A. & A. S. Andreasian. 1976. Enzyme Therapy in Organic Lesions of the Spinal Cord. E. Tanasescu, Transl. Brain Information Service. University of California. Los Angeles , Calif . 54 Rammler, D. H. 1971. Use of DMSO in enzyme-catalyzed reactions. In Dimethyl Sulfoxide. S. W. Jacob, E. E. Rosenbaum & D. C. Wood, Eds. Marcel Dekker. New York . 55 Gelderd, J. B. & M. F. St. Onge. 1977. The effect of l-thyroxine and enzyme treatments following spinal cord transection in rats: A light microscopic study. Anat. Rec. 187: 586. 56 Guth, L., E. Albuquerque, S. S. Desphande, C. P. Barrett, E. J. Donati & J. E. Warnick. 1980. Ineffectiveness of enzyme therapy on regeneration in the transected spinal cord of the rat. J. Neurosurg. 52: 73– 86. 57 Feringa, E. R., T. F. Kowalski, H. L. Vahlsing & R. A. Frye. 1979. Enzyme treatment of spinal cord transected rats. Ann. Neurol. 2: 203– 206. Citing Literature Volume411, Issue1Biological Actions and Medical Applications of Dimethyl SulfoxideJune 1983Pages 218-233 ReferencesRelatedInformation