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The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

2012; American Association for the Advancement of Science; Volume: 5; Issue: 243 Linguagem: Inglês

10.1126/scisignal.2003084

1937-9145

Ulrich Putz, Jason Howitt, Anh Doan, Choo‐Peng Goh, Ley‐Hian Low, John Silke, Seong‐Seng Tan,

RNA Interference and Gene Delivery

A tumor suppressor protein with lipid phosphatase activity is carried to target cells in microvesicles.