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Interleukin-8—An Early Marker for Bacterial Infection

2000; Oxford University Press; Volume: 31; Issue: 1 Linguagem: Inglês

10.1309/gj98-jah8-vq57-d6n0

1943-7730

Yoshio Hirao, Tsugiyasu Kanda, Yoshimasa Aso, Masato Mitsuhashi, Isao Kobayashi,

Hematological disorders and diagnostics

The cytokine network is activated in the pathogenetic mechanisms of septic diseases. We measured serum concentrations of interleukin-8 (IL-8) in 152 patients with septic syndrome and 25 control subjects. IL-8 concentration in patients with septic syndrome was significantly (P<.05) higher than in controls. Serum IL-8 concentration was assayed prospectively in 6 patients undergoing chemotherapy for leukemia. Increased IL-8 concentration preceded onset of fever and elevation of C-reactive protein by 1 day. Human peripheral whole blood cells were stimulated with phorbol 12–myristate 13–acetate (PMA), lipopolysaccharide (LPS), or lipoteichoic acid. IL-8 mRNA expression was detected 10 minutes after PMA or LPS exposure, and IL-8 was secreted into culture media 3 hours after exposure. These data suggest that IL-8 is a useful early indicator of bacterial infection.