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BIBTEX RIS

In Vitro Activity of 2,4-Diamino-6-[2-(Phosphonomethoxy)Ethoxy]-Pyrimidine against Multidrug-Resistant Hepatitis B Virus Mutants

2007; American Society for Microbiology; Volume: 51; Issue: 6 Linguagem: Inglês

10.1128/aac.01440-06

ISSN

1098-6596

Autores

Marie-No�lle Brunelle, Julie Lucifora, Johan Neyts, Stéphanie Villet, Antonı́n Holý, C. Trépo, Fabien Zoulim,

Tópico(s)

HIV/AIDS drug development and treatment

Resumo

ABSTRACT The susceptibilities of drug-resistant hepatitis B virus (HBV) mutants to lamivudine, adefovir, tenofovir, entecavir, and 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine (PMEO-DAPym), a novel acyclic pyrimidine analogue, were assessed in vitro. Most drug-resistant mutants, including multidrug-resistant strains, remained sensitive to tenofovir and PMEO-DAPym. Therefore, the latter molecule deserves further evaluation for the treatment of HBV infection.

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