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Apolipoprotein E Genotype and Age at Menopause

2004; Wiley; Volume: 1019; Issue: 1 Linguagem: Inglês

10.1196/annals.1297.105

1749-6632

Jalal Koochmeshgi, S.M. Hosseini‐Mazinani, Seyed Morteza Seifati, NASRIN HOSEIN‐PUR‐NOBARI, Ladan Teimoori‐Toolabi,

Sex and Gender in Healthcare

A bstract : We tested the hypothesis that there is a connection between apolipoprotein E ( APOE ) genotype and age at menopause. A sample of women aged between 50 and 60 years who had reached natural menopause was studied. Survival analysis of data showed a significant relationship between APOE genotype and age at menopause, carriers of the APOE 4 allele reaching menopause at an earlier age. Our findings can have a bearing on the question of the evolution of this major human polymorphism and human life history. These findings are also relevant to the question of the connection between reproductive parameters and age‐associated diseases.