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Liver Hemostasis With High‐Intensity Ultrasound

2004; Wiley; Volume: 23; Issue: 2 Linguagem: Inglês

10.7863/jum.2004.23.2.217

1550-9613

Shahram Vaezy, Misty L. Noble, Amid Keshavarzi, Marla Paun, Adrian F. Prokop, Carol Cornejo, Sam R. Sharar, Y. Emil, Lawrence A. Crum, Roy W. Martin,

Effects of Radiation Exposure

Journal of Ultrasound in MedicineVolume 23, Issue 2 p. 217-225 Article Liver Hemostasis With High-Intensity Ultrasound Repair and Healing Shahram Vaezy PhD, Corresponding Author Shahram Vaezy PhD [email protected] Applied Physics Laboratory, University of Washington, Seattle, Washington USAAddress correspondence and reprint requests to Shahram Vaezy, PhD, Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Box 355640, 1013 NE 40th St, Seattle, WA 98105.Search for more papers by this authorMisty L. Noble BS, Misty L. Noble BS Applied Physics Laboratory, University of Washington, Seattle, Washington USASearch for more papers by this authorAmid Keshavarzi MD, Amid Keshavarzi MD Department of Surgery, University of Washington, Seattle, Washington USASearch for more papers by this authorMarla Paun RDMS, Marla Paun RDMS Applied Physics Laboratory, University of Washington, Seattle, Washington USASearch for more papers by this authorAdrian F. Prokop MS, Adrian F. Prokop MS Department of Bioengineering, University of Washington, Seattle, Washington USASearch for more papers by this authorCarol Cornejo MD, Carol Cornejo MD Department of Surgery, University of Washington, Seattle, Washington USASearch for more papers by this authorSam Sharar MD, Sam Sharar MD Department of Anesthesiology, University of Washington, Seattle, Washington USASearch for more papers by this authorEmil Y. Chi PhD, Emil Y. Chi PhD Department of Pathology, University of Washington, Seattle, Washington USASearch for more papers by this authorLawrence A. Crum PhD, Lawrence A. Crum PhD Department of Bioengineering, University of Washington, Seattle, Washington USASearch for more papers by this authorRoy W. Martin PhD, Roy W. Martin PhD Applied Physics Laboratory, University of Washington, Seattle, Washington USA Department of Bioengineering, University of Washington, Seattle, Washington USASearch for more papers by this author Shahram Vaezy PhD, Corresponding Author Shahram Vaezy PhD [email protected] Applied Physics Laboratory, University of Washington, Seattle, Washington USAAddress correspondence and reprint requests to Shahram Vaezy, PhD, Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Box 355640, 1013 NE 40th St, Seattle, WA 98105.Search for more papers by this authorMisty L. Noble BS, Misty L. Noble BS Applied Physics Laboratory, University of Washington, Seattle, Washington USASearch for more papers by this authorAmid Keshavarzi MD, Amid Keshavarzi MD Department of Surgery, University of Washington, Seattle, Washington USASearch for more papers by this authorMarla Paun RDMS, Marla Paun RDMS Applied Physics Laboratory, University of Washington, Seattle, Washington USASearch for more papers by this authorAdrian F. Prokop MS, Adrian F. Prokop MS Department of Bioengineering, University of Washington, Seattle, Washington USASearch for more papers by this authorCarol Cornejo MD, Carol Cornejo MD Department of Surgery, University of Washington, Seattle, Washington USASearch for more papers by this authorSam Sharar MD, Sam Sharar MD Department of Anesthesiology, University of Washington, Seattle, Washington USASearch for more papers by this authorEmil Y. Chi PhD, Emil Y. Chi PhD Department of Pathology, University of Washington, Seattle, Washington USASearch for more papers by this authorLawrence A. Crum PhD, Lawrence A. Crum PhD Department of Bioengineering, University of Washington, Seattle, Washington USASearch for more papers by this authorRoy W. Martin PhD, Roy W. Martin PhD Applied Physics Laboratory, University of Washington, Seattle, Washington USA Department of Bioengineering, University of Washington, Seattle, Washington USASearch for more papers by this author First published: 01 February 2004 https://doi.org/10.7863/jum.2004.23.2.217Citations: 32Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Objective. Previous studies have shown that high-intensity focused ultrasound can effectively control bleeding from injuries of liver, spleen, and blood vessels. This study investigated long-term hemostasis and tissue repair after high-intensity focused ultrasound treatment in liver. Methods. A total of 21 rabbits were randomly assigned to 2 groups: high-intensity focused ultrasound treatment (n = 14) and sham treatment (n = 7). All animals had sterile laparotomy and liver exposure. The high-intensity focused ultrasound–treated animals received liver incisions, 20 to 25 mm long and 4 to 6 mm deep, followed immediately by high-intensity focused ultrasound application until complete hemostasis was achieved. After recovery, sonographic images, blood samples, and histologic samples were collected immediately and on days 1, 3, 7, 14, 28, and 60 after treatment. Results. All 14 liver injuries were hemostatic after an average ± SD of 78 ± 44 seconds of high-intensity focused ultrasound application, with no rebleeding at any time point after the treatment. Subsequent blood analysis showed no significant difference in serial hematologic or coagulation measures between the high-intensity focused ultrasound and sham groups. Alanine aminotransferase and aspartate aminotransferase levels increased immediately after surgery by as much as 285% up to day 3 and returned to normal values by day 7. Hematocrit and white blood cell counts showed no statistically significant difference from normal values at all time points. Histologic examination up to 60 days after treatment revealed scarring and liver tissue regeneration at the treatment site. Conclusions. High-intensity focused ultrasound appears to provide long-lasting hemostasis of acute liver injury. Healing and repair mechanisms after high-intensity focused ultrasound application appear to be intact. Citing Literature Volume23, Issue2February 2004Pages 217-225 RelatedInformation