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Revisado por pares
Farnesyltransferase‐Inhibitoren hemmen das Wachstum von Malaria‐Erregern in vitro und in vivo
2003; Wiley; Volume: 116; Issue: 2 Linguagem: Alemão
10.1002/ange.200351169
ISSN1521-3757
AutoresJochen Wiesner, Katja Kettler, Jacek Sakowski, Regina Ortmann, Alejandro M. Katzin, Emı́lia A. Kimura, Katrin Silber, Gerhard Klebe, Hassan Jomaa, Martin Schlitzer,
Tópico(s)Computational Drug Discovery Methods
ResumoAngewandte ChemieVolume 116, Issue 2 p. 254-257 Zuschrift Farnesyltransferase-Inhibitoren hemmen das Wachstum von Malaria-Erregern in vitro und in vivo† Jochen Wiesner Dr., Jochen Wiesner Dr. Biochemisches Institut der Justus-Liebig-Universität Gießen, Friedrichstraße 24, 35392 Gießen, DeutschlandSearch for more papers by this authorKatja Kettler, Katja Kettler Ludwig-Maximilians-Universität München, Department Pharmazie – Zentrum für Pharmaforschung, Butenandtstraße 5–13, 81377 München, Deutschland, Fax: (+49) 89-2180-79992Search for more papers by this authorJacek Sakowski Dr., Jacek Sakowski Dr. Ludwig-Maximilians-Universität München, Department Pharmazie – Zentrum für Pharmaforschung, Butenandtstraße 5–13, 81377 München, Deutschland, Fax: (+49) 89-2180-79992Search for more papers by this authorRegina Ortmann Dr., Regina Ortmann Dr. Ludwig-Maximilians-Universität München, Department Pharmazie – Zentrum für Pharmaforschung, Butenandtstraße 5–13, 81377 München, Deutschland, Fax: (+49) 89-2180-79992Search for more papers by this authorAlejandro M. Katzin Prof. Dr., Alejandro M. Katzin Prof. Dr. Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Professor Lineu Prestes, 1374, CEP 05508-900, São Paulo, BrasilienSearch for more papers by this authorEmília A. Kimura Dr., Emília A. Kimura Dr. Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Professor Lineu Prestes, 1374, CEP 05508-900, São Paulo, BrasilienSearch for more papers by this authorKatrin Silber, Katrin Silber Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032 Marburg, DeutschlandSearch for more papers by this authorGerhard Klebe Prof Dr., Gerhard Klebe Prof Dr. Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032 Marburg, DeutschlandSearch for more papers by this authorHassan Jomaa Dr., Hassan Jomaa Dr. Biochemisches Institut der Justus-Liebig-Universität Gießen, Friedrichstraße 24, 35392 Gießen, DeutschlandSearch for more papers by this authorMartin Schlitzer Prof. Dr., Martin Schlitzer Prof. Dr. [email protected] Ludwig-Maximilians-Universität München, Department Pharmazie – Zentrum für Pharmaforschung, Butenandtstraße 5–13, 81377 München, Deutschland, Fax: (+49) 89-2180-79992Search for more papers by this author Jochen Wiesner Dr., Jochen Wiesner Dr. Biochemisches Institut der Justus-Liebig-Universität Gießen, Friedrichstraße 24, 35392 Gießen, DeutschlandSearch for more papers by this authorKatja Kettler, Katja Kettler Ludwig-Maximilians-Universität München, Department Pharmazie – Zentrum für Pharmaforschung, Butenandtstraße 5–13, 81377 München, Deutschland, Fax: (+49) 89-2180-79992Search for more papers by this authorJacek Sakowski Dr., Jacek Sakowski Dr. Ludwig-Maximilians-Universität München, Department Pharmazie – Zentrum für Pharmaforschung, Butenandtstraße 5–13, 81377 München, Deutschland, Fax: (+49) 89-2180-79992Search for more papers by this authorRegina Ortmann Dr., Regina Ortmann Dr. Ludwig-Maximilians-Universität München, Department Pharmazie – Zentrum für Pharmaforschung, Butenandtstraße 5–13, 81377 München, Deutschland, Fax: (+49) 89-2180-79992Search for more papers by this authorAlejandro M. Katzin Prof. Dr., Alejandro M. Katzin Prof. Dr. Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Professor Lineu Prestes, 1374, CEP 05508-900, São Paulo, BrasilienSearch for more papers by this authorEmília A. Kimura Dr., Emília A. Kimura Dr. Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Professor Lineu Prestes, 1374, CEP 05508-900, São Paulo, BrasilienSearch for more papers by this authorKatrin Silber, Katrin Silber Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032 Marburg, DeutschlandSearch for more papers by this authorGerhard Klebe Prof Dr., Gerhard Klebe Prof Dr. Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032 Marburg, DeutschlandSearch for more papers by this authorHassan Jomaa Dr., Hassan Jomaa Dr. Biochemisches Institut der Justus-Liebig-Universität Gießen, Friedrichstraße 24, 35392 Gießen, DeutschlandSearch for more papers by this authorMartin Schlitzer Prof. Dr., Martin Schlitzer Prof. Dr. [email protected] Ludwig-Maximilians-Universität München, Department Pharmazie – Zentrum für Pharmaforschung, Butenandtstraße 5–13, 81377 München, Deutschland, Fax: (+49) 89-2180-79992Search for more papers by this author First published: 19 December 2003 https://doi.org/10.1002/ange.200351169Citations: 11 † Diese Arbeit wurde durch das INCO-Dev-Programm im fünften Rahmenprogramm der Europäischen Kommission gefördert (Vertrags-Nr. ICA4-CT-2001-10078). Wir danken Dajana Henschker für hervorragende technische Assistenz. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Die Hemmung der Farnesyltransferase wurde kürzlich als neues Prinzip in der Malariatherapie vorgeschlagen. Die hier vorgestellten Farnesyltransferase-Inhibitoren, z. B. 1, sind in vitro und erstmalig auch im Mausmodell gegen Plasmodien wirksam und reduzieren die Farnesylierung von Parasiten-Proteinen signifikant. References 1H.-W. Fu, P. J. Casey, Recent Prog. Horm. 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