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Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water

2013; Wiley; Volume: 52; Issue: 8 Linguagem: Inglês

10.1002/anie.201204464

1521-3773

Svenja Staudt, Edyta Burda, Carolin Giese, Christina Müller, Jan Marienhagen, Ulrich Schwaneberg, Werner Hummel, Karlheinz Drauz, Harald Gröger,

Metal-Catalyzed Oxygenation Mechanisms

Angewandte Chemie International EditionVolume 52, Issue 8 p. 2359-2363 Communication Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water† Svenja Staudt, Svenja Staudt Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Henkestrasse 42, 91054 Erlangen (Germany)Search for more papers by this authorEdyta Burda, Edyta Burda Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Henkestrasse 42, 91054 Erlangen (Germany)Search for more papers by this authorCarolin Giese, Carolin Giese Faculty of Chemistry, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld (Germany)Search for more papers by this authorChristina A. Müller, Christina A. Müller Institute of Biotechnology, RWTH Aachen, Worringerweg 1, 52074 Aachen (Germany)Search for more papers by this authorDr. Jan Marienhagen, Dr. Jan Marienhagen Institute of Biotechnology, RWTH Aachen, Worringerweg 1, 52074 Aachen (Germany)Search for more papers by this authorProf. Dr. Ulrich Schwaneberg, Prof. Dr. Ulrich Schwaneberg Institute of Biotechnology, RWTH Aachen, Worringerweg 1, 52074 Aachen (Germany)Search for more papers by this authorProf. Dr. Werner Hummel, Prof. Dr. Werner Hummel Institute of Molecular Enzyme Technology at the Heinrich-Heine-University of Düsseldorf, Research Centre Jülich, Stetternicher Forst, 52426 Jülich (Germany)Search for more papers by this authorProf. Dr. Karlheinz Drauz, Prof. Dr. Karlheinz Drauz Innovation Management Chemicals, International Scientific Relations, Evonik Degussa GmbH, Rodenbacher Chaussee 4, 63457 Hanau-Wolfgang (Germany)Search for more papers by this authorProf. Dr. Harald Gröger, Corresponding Author Prof. Dr. Harald Gröger harald.groeger@uni-bielefeld.de Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Henkestrasse 42, 91054 Erlangen (Germany) Faculty of Chemistry, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld (Germany)Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Henkestrasse 42, 91054 Erlangen (Germany)===Search for more papers by this author Svenja Staudt, Svenja Staudt Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Henkestrasse 42, 91054 Erlangen (Germany)Search for more papers by this authorEdyta Burda, Edyta Burda Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Henkestrasse 42, 91054 Erlangen (Germany)Search for more papers by this authorCarolin Giese, Carolin Giese Faculty of Chemistry, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld (Germany)Search for more papers by this authorChristina A. Müller, Christina A. Müller Institute of Biotechnology, RWTH Aachen, Worringerweg 1, 52074 Aachen (Germany)Search for more papers by this authorDr. Jan Marienhagen, Dr. Jan Marienhagen Institute of Biotechnology, RWTH Aachen, Worringerweg 1, 52074 Aachen (Germany)Search for more papers by this authorProf. Dr. Ulrich Schwaneberg, Prof. Dr. Ulrich Schwaneberg Institute of Biotechnology, RWTH Aachen, Worringerweg 1, 52074 Aachen (Germany)Search for more papers by this authorProf. Dr. Werner Hummel, Prof. Dr. Werner Hummel Institute of Molecular Enzyme Technology at the Heinrich-Heine-University of Düsseldorf, Research Centre Jülich, Stetternicher Forst, 52426 Jülich (Germany)Search for more papers by this authorProf. Dr. Karlheinz Drauz, Prof. Dr. Karlheinz Drauz Innovation Management Chemicals, International Scientific Relations, Evonik Degussa GmbH, Rodenbacher Chaussee 4, 63457 Hanau-Wolfgang (Germany)Search for more papers by this authorProf. Dr. Harald Gröger, Corresponding Author Prof. Dr. Harald Gröger harald.groeger@uni-bielefeld.de Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Henkestrasse 42, 91054 Erlangen (Germany) Faculty of Chemistry, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld (Germany)Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Henkestrasse 42, 91054 Erlangen (Germany)===Search for more papers by this author First published: 21 January 2013 https://doi.org/10.1002/anie.201204464Citations: 59 † We thank the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) for generous support and promotion of this work within the collaborative research centre SFB583 "Redox-Active Metal Complexes" (Sonderforschungsbereich SFB583 "Redoxaktive Metallkomplexe"). E.B. thanks the Graduate School of Molecular Science at the University of Erlangen-Nürnberg for the support of her research work. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract It doesn′t take much to oxidize cycloalkanes directly to the corresponding cyclic ketones: molecular oxygen as the oxidant, water as the solvent, the cofactor NADP+ (and a little 2-propanol to reduce it), as well as two catalytic enzymes—a hydroxylating P450 monooxygenase and an alcohol dehydrogenase (see scheme). Citing Literature Volume52, Issue8February 18, 2013Pages 2359-2363 RelatedInformation