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Artigo Revisado por pares
BIBTEX RIS

Anti-hepatitis C Virus Effect of Citrus Unshiu Peel and Its Active Ingredient Nobiletin

2005; World Scientific; Volume: 33; Issue: 01 Linguagem: Inglês

10.1142/s0192415x05002680

ISSN

1793-6853

Autores

Megumi Suzuki, Kenroh Sasaki, Fumihiko Yoshizaki, Min Fujisawa, Katsuji Oguchi, Jong‐Chol Cyong,

Tópico(s)

Bioactive natural compounds

Resumo

We investigated the effects of water and ethyl acetate extracts of Citrus unshiu peel (Aurantii Nobilis pericarpium) on hepatitis C virus (HCV) absorption in MOLT-4 cells (a human lymphoblastoid leukemia cell line). By reverse transcription polymerase chain reaction (RT-PCR), we showed that both the ethyl acetate layer of Citrus unshiu peel extract and fraction 7 decreased HCV absorption in MOLT-4 cells. Furthermore, we demonstrated that 3',4',5,6,7,8-hexamethoxyflavone (nobiletin) is the active ingredient that markedly inhibited HCV infection in MOLT-4 cells.

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