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Highly Efficient and Ultrafast Phototriggers for cAMP and cGMP by Using Long-Wavelength UV/Vis-Activation

2001; Wiley; Volume: 40; Issue: 6 Linguagem: Inglês

10.1002/1521-3773(20010316)40

1521-3773

Volker Hagen, Jürgen Bendig, Stephan Frings, Torsten Eckardt, Siegrun Helm, D. Reuter, U. Benjamin Kaupp,

Chemical Synthesis and Analysis

Caged cyclic nucleotides exhibiting remarkable advantageous properties have been developed through the use of novel photolabile coumarinylmethyl protecting groups (see scheme). They serve as excellent intracellular sources of cAMP and cGMP and allow the study of spatial- and time-dependent aspects of cyclic nucleotide signaling.