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α-Synuclein–Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons

2012; American Association for the Advancement of Science; Volume: 4; Issue: 163 Linguagem: Inglês

10.1126/scitranslmed.3004676

ISSN

1946-6242

Autores

Mickaël Decressac, Banafsheh Kadkhodaei, Bengt Mattsson, Ariadna Laguna, Thomas Perlmann, Anders Björklund,

Tópico(s)

RNA Interference and Gene Delivery

Resumo

The trophic response of dopamine neurons to GDNF, mediated by the transcription factor Nurr1, protects them from α-synuclein–mediated toxicity.

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