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Pharmacology and Toxicology of Cannabis Derivatives and Endocannabinoid Agonists

2009; Bentham Science Publishers; Volume: 5; Issue: 1 Linguagem: Inglês

10.2174/157488910789753521

2212-3954

Gilberto Gerra, Amir Zaimovic, Maria Lidia Gerra, Roberto Ciccocioppo, Andrea Cippitelli, Giovanni Serpelloni, Lorenzo Somaini,

Sleep and Wakefulness Research

For centuries Cannabis sativa and cannabis extracts have been used in natural medicine. Delta(9)-tetrahydrocannabinol (THC) is the main active ingredient of Cannabis. THC seems to be responsible for most of the pharmacological and therapeutic actions of cannabis. In a few countries THC extracts (i.e. Sativex) or THC derivatives such as nabilone, and dronabinol are used in the clinic for the treatment of several pathological conditions like chemotherapy-induced nausea and vomiting, multiple sclerosis and glaucoma. On the other hand the severe side effects and the high abuse liability of these agents represent a serious limitation in their medical use. In addition, diversion in the use of these active ingredients for recreational purpose is a concern. Over recent years, alternative approaches using synthetic cannabinoid receptor agonists or agents acting as activators of the endocannabinoid systems are under scrutiny with the hope to develop more effective and safer clinical applications. Likely, in the near future few of these new molecules will be available for clinical use. The present article review recent study and patents with focus on the cannabinoid system as a target for the treatment of central nervous system disorders with emphasis on agonists.