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Epstein-Barr virus—associated large granular lymphocyte leukemia with cutaneous infiltration

1994; Elsevier BV; Volume: 31; Issue: 2 Linguagem: Inglês

10.1016/s0190-9622(94)70157-1

1097-6787

Hideo Asada, Natsuko Okada, H Tei, Teiichi Yamamura, Koji Hashimoto, Kazuhiro Kondo, Koichi Yamanishi, Kunihiko Yoshikawa,

Lymphoma Diagnosis and Treatment

A 36-year-old man had a high titer of antibody to Epstein-Barr virus (EBV) and recurrent necrotizing papules and nodules on his face and oral mucosa. The disease was diagnosed as CD3+4− 8+ large granular lymphocyte leukemia of T-cell origin. Southern blot analysis demonstrated that EBV DNA was present in CD8+ lymphocytes; EBV antigens were also observed in these lymphocytes. These findings demonstrated that EBV latently infected the leukemic cells and may have played a role in the pathogenesis of this disease. This is the first report of an association between EBV and large granular lymphocyte leukemia of T-cell origin. A 36-year-old man had a high titer of antibody to Epstein-Barr virus (EBV) and recurrent necrotizing papules and nodules on his face and oral mucosa. The disease was diagnosed as CD3+4− 8+ large granular lymphocyte leukemia of T-cell origin. Southern blot analysis demonstrated that EBV DNA was present in CD8+ lymphocytes; EBV antigens were also observed in these lymphocytes. These findings demonstrated that EBV latently infected the leukemic cells and may have played a role in the pathogenesis of this disease. This is the first report of an association between EBV and large granular lymphocyte leukemia of T-cell origin.