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TAMO: a flexible, object-oriented framework for analyzing transcriptional regulation using DNA-sequence motifs

2005; Oxford University Press; Volume: 21; Issue: 14 Linguagem: Inglês

10.1093/bioinformatics/bti481

1367-4811

Derek B. Gordon, Lena Nekludova, Scott A. McCallum, Ernest Fraenkel,

RNA Research and Splicing

Summary: TAMO (Tools for Analysis of MOtifs) is an object-oriented computational framework for interpreting transcriptional regulation using DNA-sequence motifs. To simplify the application of multiple motif discovery programs to genome-wide data, TAMO provides a sophisticated motif object with interfaces to several popular programs. In addition, TAMO provides modules for integrating motif analysis with diverse data sources including genomic sequences, microarrays and various databases. Finally, TAMO includes tools for sequence analysis, algorithms for scoring, comparing and clustering motifs, and several useful statistical tests. Recently, we have applied these tools to analyze tens of thousands of motifs derived from hundreds of microarray experiments.