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Pericellular Hydrogel/Nanonets Inhibit Cancer Cells

2014; Wiley; Volume: 53; Issue: 31 Linguagem: Inglês

10.1002/anie.201402216

1521-3773

Yi Kuang, Junfeng Shi, Jie Li, Dan Yuan, Kyle A. Alberti, Qiaobing Xu, Bing Xu,

Nanoplatforms for cancer theranostics

Abstract Fibrils formed by proteins are vital components for cells. However, selective formation of xenogenous nanofibrils of small molecules on mammalian cells has yet to be observed. Here we report an unexpected observation of hydrogel/nanonets of a small D ‐peptide derivative in pericellular space. Surface and secretory phosphatases dephosphorylate a precursor of a hydrogelator to trigger the self‐assembly of the hydrogelator and to result in pericellular hydrogel/nanonets selectively around the cancer cells that overexpress phosphatases. Cell‐based assays confirm that the pericellular hydrogel/nanonets block cellular mass exchange to induce apoptosis of cancer cells, including multidrug‐resistance (MDR) cancer cells, MES‐SA/Dx5. Pericellular hydrogel/nanonets of small molecules to exhibit distinct functions illustrates a fundamentally new way to engineer molecular assemblies spatiotemporally in cellular microenvironment for inhibiting cancer cell growth and even metastasis.