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Verapamil in the prophylaxis of episodic cluster headache: A double-blind study versus placebo

2000; Lippincott Williams & Wilkins; Volume: 54; Issue: 6 Linguagem: Inglês

10.1212/wnl.54.6.1382

1526-632X

Massimo Leone, Domenico D’Amico, Fabio Frediani, F. Moschiano, Licia Grazzi, Aldo Attanasio, G. Bussone,

Neurological Complications and Syndromes

Article abstract The authors performed a double-blind, double-dummy study to compare the efficacy of verapamil with placebo in the prophylaxis of episodic cluster headache. After 5 days' run-in, 15 patients received verapamil (120 mg tid) and 15 received placebo (tid) for 14 days. The authors found a significant reduction in attack frequency and abortive agents consumption in the verapamil group. Side effects were mild. These findings provide objective evidence for the effectiveness of verapamil in episodic cluster headache prophylaxis.