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BIBTEX RIS

Association between the 1858T allele of the protein tyrosine phosphatase nonreceptor type 22 and type 1 diabetes in a Brazilian population

2010; Wiley; Linguagem: Inglês

10.1111/j.1399-0039.2010.01480.x

1399-0039

Pedro César Chagastelles, Mírian Romitti, Márcia Rodrigues Trein, Eliane Bandinelli, Balduíno Tschiedel, Nance Beyer Nardi,

Protein Tyrosine Phosphatases

The 1858T allele of the protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene has been associated to diabetes in different populations. We investigated a possible relationship between this polymorphism and type 1 diabetes in a cohort of Brazilian patients. A significantly higher frequency of the 1858T allele was observed in diabetic patients (n = 211) than in control individuals (n = 241). Additionally, the heterozygote genotype was also increased in the diabetic group. No association was observed between the PTPN22 T allele and gender, or between T carriers and age of onset of T1D. This work describes for the first time a strong association of the 1858T allele with type 1 diabetes in a Brazilian population, reinforcing the role of this variant as an important susceptibility factor for this disease.