Portal de Periódicos da CAPES

Melanocyte-marker-HMB-45 is regularly expressed in angiomyolipoma of the kidney

1991; Elsevier BV; Volume: 23; Issue: 3 Linguagem: Inglês

10.3109/00313029109063563

1465-3931

Maurizio Pea, Franco Bonetti, Giuseppe Zamboni, Guido Martignoni, Maurizio Riva, Romano Colombari, Aldo Mombello, Mariella Bonzanini, Aldo Scarpa, Claudio Ghimenton, L Donati,

Tuberous Sclerosis Complex Research

HMB-45 (melanocytic cell-specific monoclonal antibody) immunoreactivity was investigated in 10 cases of angiomyo-lipoma (AML) (1 with massive regional lymph node involvement) of the kidney and detected in all of them. No HMB-45 immunoreactivity was found in other tumors of the region which can occasionally be confused with AML, such as renal cell carcinoma, Wilms’ tumor, and retroperitoneal sarcoma (leiomyosarcoma and liposarcoma). These findings indicate that HMB-45 is not a melanocyte-restricted marker and suggest that its expression might be useful in distinguishing AML from other tumors of the kidney and retroperitoneum.