Risk for myasthenia gravis maps to a 151 Pro→Ala change in TNIP1 and to human leukocyte antigen‐B*08
2012; Wiley; Volume: 72; Issue: 6 Linguagem: Inglês
10.1002/ana.23691
ISSN1531-8249
AutoresPeter K. Gregersen, Roman Kosoy, Annette T. Lee, Janine A. Lamb, Jon Sussman, David McKee, Kim R. Simpfendorfer, R. Pirskanen‐Matell, Fredrik Piehl, Qiang Pan‐Hammarström, Jan J.G.M. Verschuuren, Maarten J. Titulaer, Erik H. Niks, Alexander Marx, Philipp Ströbel, Björn Tackenberg, Michael Pütz, Angelina Maniaol, Ahmed Elsais, Chantal Tallaksen, Hanne F. Harbo, Benedicte A. Lie, Soumya Raychaudhuri, Paul I. W. de Bakker, Arthur Melms, Henri‐Jean Garchon, Nicholas Willcox, Lennart Hammarström, Michael F. Seldin,
Tópico(s)Protein Tyrosine Phosphatases
ResumoThe objective of this study is to comprehensively define the genetic basis of early onset myasthenia gravis (EOMG).We have carried out a 2-stage genome-wide association study on a total of 649 North European EOMG patients. Cases were matched 1:4 with controls of European ancestry. We performed imputation and conditional analyses across the major histocompatibility complex, as well as in the top regions of association outside the human leukocyte antigen (HLA) region.We observed the strongest association in the HLA class I region at rs7750641 (p = 1.2 × 10(-92) ; odds ratio [OR], 6.25). By imputation and conditional analyses, HLA-B*08 proves to be the major associated allele (p = 2.87 × 10(-113) ; OR, 6.41). In addition to the expected association with PTPN22 (rs2476601; OR, 1.71; p = 8.2 × 10(-10) ), an imputed coding variant (rs2233290) at position 151 (Pro→Ala) in the TNFAIP3-interacting protein 1, TNIP1, confers even stronger risk than PTPN22 (OR, 1.91; p = 3.2 × 10(-10) ).The association at TNIP1 in EOMG implies disease mechanisms involving ubiquitin-dependent dysregulation of NF-κB signaling. The localization of the major HLA signal to the HLA-B*08 allele suggests that CD8(+) T cells may play a key role in disease initiation or pathogenesis.
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