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Mechanisms of chloroquine resistance in malarial chemotherapy

1988; Elsevier BV; Volume: 9; Issue: 7 Linguagem: Inglês

10.1016/0165-6147(88)90153-8

1873-3735

Stephen A. Ward,

Pharmacogenetics and Drug Metabolism

Malaria is a protozoan parasitic infection threatening millions of people throughout the world. Over 6 million cases of malaria are treated annually and in Africa alone one million infant deaths can be attributed directly to malaria. Chloroquine has been the mainstay of malaria chemotherapy for nearly 50 years, but widespread resistance now limits its usefulness. Stephen Ward outlines the pharmacology of this drug. possible mechanisms of parasite resistance and pharmacologically based strategies that may be useful in attempting to override this resistance.