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Comparing the clinical outcomes in stereotactic body radiotherapy for lung tumors between Ray-Tracing and Monte-Carlo algorithms

2015; Impact Journals LLC; Volume: 7; Issue: 14 Linguagem: Inglês

10.18632/oncotarget.5992

1949-2553

Jin Ho Song, Ki Mun Kang, Hoon‐Sik Choi, Hojin Jeong, In Bong Ha, Jong Deog Lee, Ho Cheol Kim, Yi Yeong Jeong, Yu Ji Cho, Seung Jun Lee, Sung Hwan Kim, In Seok Jang, Bae Kwon Jeong,

Medical Imaging Techniques and Applications

// Jin Ho Song 1, 4 , Ki Mun Kang 1, 4 , Hoon-Sik Choi 1 , Hojin Jeong 1, 4 , In Bong Ha 1, 4 , Jong Deog Lee 2 , Ho Cheol Kim 2 , Yi Yeong Jeong 2 , Yu Ji Cho 2 , Seung Jun Lee 2 , Sung Hwan Kim 3 , In-Seok Jang 3 , Bae Kwon Jeong 1, 4 1 Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea 2 Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea 3 Department of Thoracic and Cardiovascular Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea 4 Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea Correspondence to: Bae Kwon Jeong, e-mail: blue129j@gnu.ac.kr Keywords: stereotactic body radiotherapy, lung cancer, calculation algorithm, CyberKnife, Monte Carlo Received: August 10, 2015 Accepted: October 01, 2015 Published: October 26, 2015 ABSTRACT Purpose: The purpose of this study was to compare the clinical outcomes between the groups using Ray-Tracing (RAT) and Monte-Carlo (MC) calculation algorithms for stereotactic body radiotherapy (SBRT) of lung tumors. Materials and Methods: Thirty-five patients received SBRT with CyberKnife for 47 primary or metastatic lung tumors. RAT was used for 22 targets in 12 patients, and MC for 25 targets in 23 patients. Total dose of 48 to 60 Gy was prescribed in 3 to 5 fractions on median 80% isodose line. The response rate, local control rate, and toxicities were compared between RAT and MC groups. Results: The response rate was lower in the RAT group (77.3%) compared to the MC group (100%) ( p = 0.008). The response rates showed an association with the mean dose to the gross tumor volume, which the doses were re-calculated with MC algorithm in both groups. However, the local control rate and toxicities did not differ between the groups. Conclusions: The clinical outcome and toxicity of lung SBRT between the RAT and MC groups were similar except for the response rate when the same apparent doses were prescribed. The lower response rate in the RAT group, however, did not compromise the local control rates. As such, reducing the prescription dose for MC algorithm may be performed but done with caution.