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Job Stress, Gene Polymorphism of β2-AR, and Prevalence of Hypertension

2008; Elsevier BV; Volume: 21; Issue: 3 Linguagem: Inglês

10.1016/s0895-3988(08)60036-7

2214-0190

Shanfa Yu, Wenhui Zhou, Kaiyou Jiang, Gui-Zheng GU, Sheng Wang,

Cardiovascular and exercise physiology

To study the interactive effect of job stress and genetic susceptibility (or gene polymorphism) on hypertension.A cross-sectional epidemiological study was conducted in 452 workers from a thermal power plant in China. Extrinsic effort, occupational reward, and over-commitment were measured. Hypertensive patients were defined by three phases of screening, reexamination, and final diagnosis. beta2-AR genotypes and allele frequencies at amino acid positions 16 (beta2-AR-16: Arg-->Gly) and 27 (beta2-AR-27: Gln-->Glu) were identified by PCR-RFLP.Job stress was related with the prevalence of hypertension in males (P < 0.05), whereas no significant relationship was found in females (P > 0.05). Differences in genotypes and allele frequencies of the beta2-AR-16 were statistically significant between the hypertension and control groups (P < 0.05), whereas those of beta2-AR-27 were not (P > 0.05). The prevalence of hypertension was higher in individuals carrying Gly16 allele than in those carrying Arg16 allele of the high job stress group (P < 0.01 or 0.05).High job stress and polymorphism of beta2-AR-16 have an interactive effect on the prevalence of hypertension in male workers.