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Sortase transpeptidases: Insights into mechanism, substrate specificity, and inhibition

2010; Wiley; Volume: 94; Issue: 4 Linguagem: Inglês

10.1002/bip.21472

1097-0282

Kathleen Clancy, Jeffrey A. Melvin, Dewey G. McCafferty,

Botanical Research and Chemistry

Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram-positive bacterial [corrected] enzyme sortase.