Portal de Periódicos da CAPES

Design of a Gated Molecular Proton Channel

2010; Wiley; Volume: 50; Issue: 3 Linguagem: Inglês

10.1002/anie.201002564

1521-3773

Wei Gu, Bo Zhou, Tihamér Geyer, Michael C. Hutter, Haiping Fang, Volkhard Helms,

Electrochemical Analysis and Applications

Angewandte Chemie International EditionVolume 50, Issue 3 p. 768-771 Communication Design of a Gated Molecular Proton Channel† Dr. Wei Gu, Dr. Wei Gu Zentrum für Bioinformatik, Universität des Saarlandes, 66041 Saarbrücken (Germany), Fax: (+49) 681-302-64180 Center of Computational Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China)Search for more papers by this authorBo Zhou, Bo Zhou Shanghai Institute of Applied Physics, Chinese Academy of Sciences, PO Box 800-204, Shanghai 201800 (China) Graduate School of the Chinese Academy of Sciences, Beijing 100080 (China)Search for more papers by this authorDr. Tihamér Geyer, Dr. Tihamér Geyer Zentrum für Bioinformatik, Universität des Saarlandes, 66041 Saarbrücken (Germany), Fax: (+49) 681-302-64180Search for more papers by this authorDr. Michael Hutter, Dr. Michael Hutter Zentrum für Bioinformatik, Universität des Saarlandes, 66041 Saarbrücken (Germany), Fax: (+49) 681-302-64180Search for more papers by this authorProf. Dr. Haiping Fang, Corresponding Author Prof. Dr. Haiping Fang fanghaiping@sinap.ac.cn Shanghai Institute of Applied Physics, Chinese Academy of Sciences, PO Box 800-204, Shanghai 201800 (China) Haiping Fang, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, PO Box 800-204, Shanghai 201800 (China) Volkhard Helms, Zentrum für Bioinformatik, Universität des Saarlandes, 66041 Saarbrücken (Germany), Fax: (+49) 681-302-64180Search for more papers by this authorProf. Dr. Volkhard Helms, Corresponding Author Prof. Dr. Volkhard Helms volkhard.helms@bioinformatik.uni-saarland.de Zentrum für Bioinformatik, Universität des Saarlandes, 66041 Saarbrücken (Germany), Fax: (+49) 681-302-64180 Haiping Fang, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, PO Box 800-204, Shanghai 201800 (China) Volkhard Helms, Zentrum für Bioinformatik, Universität des Saarlandes, 66041 Saarbrücken (Germany), Fax: (+49) 681-302-64180Search for more papers by this author Dr. Wei Gu, Dr. Wei Gu Zentrum für Bioinformatik, Universität des Saarlandes, 66041 Saarbrücken (Germany), Fax: (+49) 681-302-64180 Center of Computational Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China)Search for more papers by this authorBo Zhou, Bo Zhou Shanghai Institute of Applied Physics, Chinese Academy of Sciences, PO Box 800-204, Shanghai 201800 (China) Graduate School of the Chinese Academy of Sciences, Beijing 100080 (China)Search for more papers by this authorDr. Tihamér Geyer, Dr. Tihamér Geyer Zentrum für Bioinformatik, Universität des Saarlandes, 66041 Saarbrücken (Germany), Fax: (+49) 681-302-64180Search for more papers by this authorDr. Michael Hutter, Dr. Michael Hutter Zentrum für Bioinformatik, Universität des Saarlandes, 66041 Saarbrücken (Germany), Fax: (+49) 681-302-64180Search for more papers by this authorProf. Dr. Haiping Fang, Corresponding Author Prof. Dr. Haiping Fang fanghaiping@sinap.ac.cn Shanghai Institute of Applied Physics, Chinese Academy of Sciences, PO Box 800-204, Shanghai 201800 (China) Haiping Fang, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, PO Box 800-204, Shanghai 201800 (China) Volkhard Helms, Zentrum für Bioinformatik, Universität des Saarlandes, 66041 Saarbrücken (Germany), Fax: (+49) 681-302-64180Search for more papers by this authorProf. Dr. Volkhard Helms, Corresponding Author Prof. Dr. Volkhard Helms volkhard.helms@bioinformatik.uni-saarland.de Zentrum für Bioinformatik, Universität des Saarlandes, 66041 Saarbrücken (Germany), Fax: (+49) 681-302-64180 Haiping Fang, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, PO Box 800-204, Shanghai 201800 (China) Volkhard Helms, Zentrum für Bioinformatik, Universität des Saarlandes, 66041 Saarbrücken (Germany), Fax: (+49) 681-302-64180Search for more papers by this author First published: 17 December 2010 https://doi.org/10.1002/anie.201002564Citations: 11 † This work was supported by the DFG (grant He3875/9-1), the PNNL (project EMSL GC 20896), the BMBF (grant CHN08/028), the NNSFC (grant 10825520), and the NBRPC (grant 2007CB936000). NWchem Version 4.7, as developed and distributed by the Pacific Northwest National Laboratory (PNNL), Richland, WA (USA), and funded by the U.S. Department of Energy, was used for some of the calculations. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract A molecular revolving door: A gated molecular proton channel that can efficiently transport protons under electric fields was designed and tested in molecular dynamics simulations. In this proton channel a rotatable chemical group, which is attached to the inner wall of the nanopore, serves as the gate and the external electric field as energy source. The binding and release of a proton leads to the opening and closing of the gate, respectively. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201002564_sm_miscellaneous_information.pdf349 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume50, Issue3January 17, 2011Pages 768-771 RelatedInformation