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Unconjugated Bilirubin and an Increased Proportion of Bilirubin Monoconjugates in the Bile of Patients with Gilbert's Syndrome and Crigler-Najjar Disease

1977; American Society for Clinical Investigation; Volume: 60; Issue: 5 Linguagem: Inglês

10.1172/jci108877

1558-8238

Johan Fevery, Norbert Blanckaert, Karel P.M. Heirwegh, Anne-Marie Préaux, Pièrre Berthelot,

Heme Oxygenase-1 and Carbon Monoxide

Bilirubin pigments were studied in the bile of 20 normal adults, 25 patients with Gilbert's syndrome, 9 children with Crigler-Najjar disease, and 6 patients with hemolysis, to determine how a deficiency of hepatic bilirubin UDP-glucuronosyltransferase would affect the end products of bilirubin biotransformation.